67 培養細胞による外来物質の生物交換 : 官能基によって支配される変換の特異性

概要

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The ability of plant cultured cells to metabolize foreign substrates is considerably interest, because the specific transformation may take place by the cells. In connection of such a study, we have examined the ability of Nicotiana tabacum suspension cells to transform the monoterpenoid alcohols and ketones as the foreign substrate. It was found that the cultured cells have the ability (i) to hydroxylate stereoselectively the C-C double bond as well as its allylic positions, (ii) to reduce stereospecifically the C-C double bond adjacent to the carbonyl group from the si-face and the carbonyl group from the re-face, and (iii) to hydrolyze the acetoxyl and the hydroxyimino groups. Furthermore, (iv) the conversion between the cyclic ketones and their corresponding alcohols was reversible, and the balance of the interconversion reaction depended on the ring size of the substrate. These results indicated that such abilities of the tobacco cells to transform foreign substrates are dominated by the functional group of the substrates and the structural varieties around the functional group.
天然有機化合物討論会の論文
1981-09-10