36 Trichothecinおよび関連物質の生合成
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概要
- 論文の詳細を見る
From the unsaponifiable fraction of the fermentation materials of Trichothecium roseum 6157, a trichothecin producing fungus, were isolated four sesquiterpenes, III, XIV, XVII, and XXIV, all of which are thought to be biogenetically related to trichothecin (I). Their structures were determined by spectral properties of the various derivatives and/or by chemical interrelation with known compounds. Feeding experiments of [4(R), 4-^3H-2-^<14>C] MVA and the subsequent degradation of the resulting trichothecolone showed that one of the radioactive carbon atoms (C-2 of MVA) is located at C-8 as shown in XXV, which is in disagreement with the earlier work. Tritium-labelled trichodiene (XXXIII) was prepared and fed to T. roseum 6157. The radioactive trichodiene was shown to be incorporated into the trichothecolone, giving an evidence that the hydrocarbon, trichodiene, is the intermediate in the biosynthesis of trichothecin. Possible biosynthetic route is given in the scheme.
- 天然有機化合物討論会の論文
- 1971-10-01
著者
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野副 重男
Institute Of Applied Microbiology The University Of Tokyo:(present Address)pharmaceutical Institute
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野副 重男
東大応微研
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町田 善正
東大応微研
関連論文
- 5.Ophiobolinの構造
- Stereo-chemistry of Steroids Containing Aromatic A-Ring. III. Hydrogenation of 11β-Hydroxy-⊿^8-dehydroestrone.
- Steroid Studies. XLIII. An Aromatization Reaction of a Cross Conjugated Dienone System with Zinc. (8).
- 23 Geranylfarnesyl Pyrophosphateの酵素的閉環 : 無細胞系によるsesterterpeneの生合成研究
- 12 hirsuteneの分離と構造決定
- (19) イネに含まれる抗白葉枯病菌物質について (I) (昭和51年度地域部会講演要旨(秋季関東部会))
- The Molecular and Crystal Structures of Two Derivatives of a Sesterterpene, Ophiobolin D
- Synthetic Studies on Marasmane and iso-Marasmane Derivatives
- 36 Trichothecinおよび関連物質の生合成
- 41 シッカニンの生合成
- 41 シッカニン,シッカノクロメンおよびその関連物貭の単離,構造およびそれらの合成的研究
- 33 セスターテルペン,セファロン酸の構造
- 25.立体化学を加味したセスキテルペンの生合成機構
- Stereochemistry of Steroids containing Aromatic A-Ring. II. Reaction of 9α, 11α-Epoxyestrone.
- Stereochemistry of Steroid containing Aromatic A-Ring. I. Reaction of 9 (11)-Dehydroestrone.
- Steroid Studies. XXI. On the Reaction of 5α, 8α-Ethylenic Steroids.
- Untersuchungen uber Steroide. XIII. Mattox-Umlagerung von Reichsteins Substanz S bei der Ketalisierung mit 2-Methyl-2-athyl-1,3-dioxolan.
- Steroid Studies. XII. On the Methylation of 3-Oxosteroids. (2).
- Steroid Studies. XI. On the Methylation of 3-Oxosteroids. (1).
- (127) いもち病菌の生産するtenuazonic acidおよびその類縁化合物のいもち病防除効果について (昭和47年度 日本植物病理学会大会)
- Structure and Chemistry of Some Ophiobolin D Derivatives