環境内分泌撹乱物質関連化合物の化学合成

概要

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Triton X (4-tert-octylphenol polyethoxylate), a multi-purpose surfactant, degrades into 4-tert-octylphenol ethoxylates, 4-tert-octylphenol and related substances by microbial organisms or UV radiation in nature. Some of the compounds are reported to be estrogenic (i.e. endocrine disruptive) to animals including humans. Therefore, a series of Triton X-related substances were synthesized as authentic references, from 4-tert-octylphenol, to identify unknown chemicals detected in the environment. Their yield rates varied from 88 to 97% for 4-tert-octylphenol ethoxylates, from 8 to 45% for 4-tert-octylphenol ethoxycarboxylates and from 31 to 70% for nonylphenol ethoxylates. NMR and GC/MS data demonstrated that the structures of synthesized chemicals were identical with their theoretical ones.
九州共立大学の論文