Sub-acute Toxicosis Caused by a Multiple Doses Tegafur/Uracil (UFT) for Suicide : A Case Report
スポンサーリンク
概要
- 論文の詳細を見る
Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative offluorouracil (5-FU) and uracil in a molar ratio of 1:4. UFT is effective as adjuvant chemotherapy forbreast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and othertumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur: 40000 mg/uracil 9960mg)in an effort to commit suicide, and suffered from sub-acute toxicosis(main symptoms werebone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemicaltreatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G-CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF arenecessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case ofno stem cells, bone marrow transfusion should be thought.
- 北関東医学会の論文
- 2007-11-01
著者
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HANDA Hiroshi
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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OGINO Takashi
Department of Radiology, National Cancer Center Hospital Ease
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YAMADA Takuro
Department of Gynecology, National Cancer Center Research Institute and Hospital
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Ogino Takashi
Department Of Radiation Oncology National Cancer Center Hospital East
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Handa Hiroshi
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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IINO Yuichi
Department of Surgery II, Gunma University Faculty of Medicine
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Yamada Takuro
Department Of Emergency Medicine Gunma University Graduate School Of Medicine
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Takahashi Yuga
Department of Emergency Medicine
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Hagiwara Shuichi
Department of Emergency Medicine
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Isaka Akira
Department of Emergency Medicine
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Nameki Taro
Department of Emergency Medicine
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Kagoshima Kaie
Department of Emergency Medicine
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Ishihara Kouichi
Department of Emergency Medicine, Gunma University, Graduate School of Medicine
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Hiraishi Hikaru
Department of Emergency Medicine
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Kurabayashi Kazutaka
Department of Medicine and Clinical Science, Gunma University, Graduate School of Medicine
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Iino Yuichi
Department Of Emergency Medicine Gunma University Graduate School Of Medicine
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Nameki Taro
Department Of Emergency Medicine Gunma University Graduate School Of Medicine
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Isaka Akira
Department Of Emergency Medicine Gunma University Graduate School Of Medicine
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Takahashi Yuga
Department Of Emergency Medicine Gunma University Graduate School Of Medicine
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Kagoshima Kaie
Department Of Emergency Medicine Gunma University Graduate School Of Medicine
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Iino Yuichi
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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Handa Hiroshi
Department Of Bioscience And Biotechnology Tokyo Institute Of Technology
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Ogino Takashi
Department Of Mechanical Engineering Tsuruoka National College Of Technology
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Kurabayashi Kazutaka
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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Ishihara Kouichi
Department Of Emergency Medicine Gunma University Graduate School Of Medicine
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Hagiwara Shuichi
Department of Emergency Medicine, Gunma University, Graduate School of Medicine
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Ogino Takashi
Department of Emergency Medicine, Gunma University, Graduate School of Medicine
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Ogino Takashi
Department of Chemistry, Faculty of Science, The University of Tokyo
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