True Local Recurrences or New Primary Tumors after Breast-Conserving Surgery and Radiation Therapy

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Background& Aims: True local recurrences(TR)and new primary tumors(NP)in the conserved breastafter breast-conserving surgery with radiation therapy are determined by the initial surgical margin, thelocation of recurrent tumors and the histological consistency between initial tumors and recurrent tumors.Methods: A total of 15 patients with breast recurrence out of a group of 389 women with breast cancerwho underwent breast-conserving therapy between 1991 and 2003 were included in this study. Thebiological differences between TR and NP were examined. Results: Eight patients had TR, and sevenhad NP. The disease-free interval was 34.6 months in the TR group and 94.1 in the NP group.Breast-free survival was significantly better in the NP group than the TR group. The accumulated10-year overall survival after salvage surgery in patients with TR or NP tumors was 85.1％. Theaccumulated overall survival after salvage surgery was better in the NP group than the TR group.Conclusions: Patients with NP tumors have a favorable prognosis compared to those with TR tumors.It is important to determine the type of breast recurrence in order to accurately predict the prognosis ofpatients with breast recurrence.
北関東医学会の論文
2007-08-01