Identification of Distinct Pathways for Superoxide Generation in Mouse Macrophages: An Investigation Using a Chemiluminescence Probe Specific for Superoxide Anion(Biological Chemistry)
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概要
- 論文の詳細を見る
Dependency of superoxide anion (O2-) generation on protein kinase C (PKC) or calmodulin (CaM) in macrophages (MPs) was investigated using a O2--specific chemiluminescence probe with the Cypridina luciferin analog 2-methyl-6-(p-niethoxyphenyl)-3, 7-dihydroimidazo[1, 2-a]-pyrazin-3-one (MCLA). In opsonized zymosan (OZ)-stimulated MPs, 40% of the MCLA-dependent chemiluminescence disappeared when the PKC inhibitor 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) or the CaM antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) was added. In MPs stimulated by 12-o-tetradecanoylphorbol-13-acetate (TPA), addition of H-7 strikingly lowered MCLA-dependent Chemiluminescence, but W-7 had only a little effect. These results indicate that both PKC and CaM are involved in OZ-stimulated O2- generation in MPs and that TPA-stimulated O2- generation depends not on CaM but on PKC.
- 社団法人日本農芸化学会の論文
- 1989-05-23
著者
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Kimura Shuichi
Faculty Of Agriculture Tohoku University
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Hosono Akiyoshi
Department Of Animal Husbandry Faculty Of Agriculture Shinsyu University
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Kimura S
Protein Engineering Research Inst. Osaka Jpn
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Inaba Humio
Biophoton Project Research Development Corporation Of Japan (jrdc):research Institute Of Electrical
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Hosono Akira
Faculty Of Agriculture Tohoku University
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Mashiko Shinroh
Biophoton Project Research Development Corporation Of Japan(jrdc):(present Office)communications Res
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INABA Humio
Yamagata Advanced Technology Research and Development Center, Tohoku Institute of Technology
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HISHINUMA Kohya
Biophoton Project, Research Development Corporation of Japan
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Inaba Humio
Yamagata Advanced Technology Research And Development Center Tohoku Institute Of Technology
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Hishinuma Kiyoshi
Biophoton Project Research Development Corporation Of Japan
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Mashiko Shinroh
Biophoton Project Research Development Corporation Of Japan
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