Relationship of Serum Adiponectin Level to Adverse Cardiovascular Events in Patients Who Undergo Percutaneous Coronary Intervention
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概要
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Background Hypoadiponectinemia has been reported to indicate an increased risk of cardiovascular disease, so the present study investigated the significance of serum adiponectin (APN) levels for predicting clinical outcomes after percutaneous coronary intervention (PCI). Methods and Results The APN levels were evaluated in 184 consecutive patients who underwent PCI. The patients were divided into Group A [the lowest quartile of APN levels (APN <4.5μg/ml), n=46] and Group B [the upper 3 quartiles of APN levels (APN >4.5μg/ml), n=138]. During a mean follow-up period of 27.3 months, the rate of major adverse cardiac and cerebrovascular events (MACCE: death from any cause, re-infarction, repeat coronary revascularization, hospitalization because of congestive heart failure, and cerebral infarction) was higher in Group A (58.7%) than in Group B (37.0%, p=0.0101). Moreover, when the APN levels were calculated by adjusting for sex, age, body mass index, and triglyceride levels, patients in the lowest quartile of residual APN levels had a higher risk of MACCE (p=0.0405). Multiple logistic analyses showed that hypoadiponectinemia (APN <4.5μg/ml) was independently correlated with MACCE. Kaplan-Meier analysis demonstrated a higher MACCE rate in Group A than in Group B (Log-rank X^2=7.89, p=0.0050). Conclusion The APN level may be helpful for predicting clinical outcomes after PCI.
- 社団法人日本循環器学会の論文
- 2007-04-20
著者
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Takeuchi Yuzo
Department of Internal Medicine, Prefectural Amagasaki Hospital
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Matsuda Mitsuo
Department of Internal Medicine, The University of Tsukuba
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Shioji Keisuke
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Shioji Keisuke
Department Of Cardiology Kishiwada City Hospital
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Moriwaki Soji
Department of Cardiology, Kishiwada City Hospital
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Uegaito Takashi
Department of Cardiology, Kishiwada City Hospital
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Takeuchi Yuzo
Department Of Cardiology Kishiwada City Hospital
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Matsuda Mitsuo
Department Of Cardiology Kishiwada City Hospital
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Mutsuo Satoru
Department of Cardiovascular Medicine, Kishiwada City Hospital
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Mutsuo Satoru
Department Of Cardiology Kishiwada City Hospital
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Moriwaki Soji
Department Of Cardiology Kishiwada City Hospital
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Uegaito Takashi
Department Of Cardiology Kishiwada City Hospital
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