1型糖尿病患者におけるインスリングラルギンの血糖改善効果と低血糖発現頻度の検討

概要

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To evaluate the effects of switching from NPH insulin (twice daily) to insulin glargine on blood glucose control (HbA_<1c>), insulin dosage and frequency of hypoglycemia in Japanese patients with type 1 diabetes, we monitored these parameters in 37 type 1 diabetics for 12 months after switching. The patients were assigned to 3 groups according to HbA_<1c> at switching : good (<7.0%), fair (7.0-7.9%) and poor (≧8.0%). Though there was no improvement in HbA_<1c> in the good and fair groups over the 12months, there was a significant decrease in HbA_<1c> in the poor group (10.2±1.2%→9.2±1.2%, p<0.01). Over this period, total dosage and basal dosage significantly decreased as compared to the time of switching. In the good and poor control groups, there was a significant decrease in the frequency of hypoglycemia. In conclusion, insulin glargine improves glycemic control in patients with type 1 diabetes mellitus, especially in patients with poor blood glucose control.
日本医療薬学会の論文
2007-03-10