Effects of Preservation Procedures on the Biomechanical and Osteoinductive Properties of Rabbit Bone

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This study was undertaken in order to clarify the effects of physical or chemical processing of allogeneic bones on their osteoinductive property and mechanical strength. Grafts harvested from the iliac crests of rabbits were processed to obtain frozen, freeze-dried and decalcified bones. Fresh autogenous and allogeneic bones were used as controls. Experiments of osteoinduction were carried out with iliac bone of rabbits by orthotopic grafting. Eight weeks after grafting, the grafted bones were removed to obtain histological specimens. For the decalcified specimens, the area ratio of new bone to graft bone trabecula was calculated and reported as "a histological incorporation ratio". And for the undecalcified specimens, the osteoid mineralization velocity was calculated. These two parameters were compared between each processed bone and the controls. The mechanical strength test was performed on the femurs of rabbits. Specimens 1cm long, which were excised from the femoral diaphyses were processed similarly and compared to fresh bones with respect mechanical strength. As a result, it was found that the freeze-dried bones had significantly higher compressive strength than the fresh and frozen ones. With respect to elastic modulus and maximum strain, on the contrary, the fresh bones yielded the highest value. The decalcified bones were found to have an extremely low value of elastic modulus and low compressive strength. The relative sequence of the incorporation ratio, a measure of osteoinductive property, was fresh autogenous bones > processed allogeneic bones > fresh allogeneic bones.
北里大学の論文
1992-08-31

Effects of Preservation Procedures on the Biomechanical and Osteoinductive Properties of Rabbit Bone

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