塩酸ニカルジピンの大量服用による死亡例

概要

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Fatal nicardipine intoxication was analyzed in one case described in the present study. A 50-year-old man suffering from hypertension and depression, took about 2.5 g of nicardipine (the amount estimated from postmortem gastric content and conditions). The man was found dead in his car. The body, 169 cm long and weighing 65.5 kg, showed marked dermahemia in the hands and feet and petechiae were congested observed in the inferior extremity. Almost all the organs were heavily congested with petechial hemorrhage, as seen under macroscopical and microscopical examination. The gastric contents 125 ml of light-brown liquid with flecks of solid material, contained 11 mg/ml of nicardipine and infrared, visible and ultra-violet spectrophotometry. Calcium-antagonistic effects of nicardipine on the human cardiac conduction system are masked by an enhanced sympathetic tone through an autonomic nerve reflex attributed to systemic hypotension. Findings in this case suggest that a depression-induced disorder of the man's nervous system effected the nicardipine intoxication.
北里大学の論文
1988-06-30