姿勢変動時のウェーブレット変換を用いた振戦疾患鑑別手法の基礎研究

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The vibration called tremor is widely observed in human beings. In the medical field, the many diseases display tremor which is typically represented by Parkinson's disease (PD) and essential tremor (ET). The number of patients with PD is about 100,000 in Japan and will increase in the future. PD has three typical signs, namely tremor, rigidity, and hypokinesia. Tremor is the most dominant symptom in the triad. It is difficult to discriminate PD from several other tremor diseases simulating Parkinson's symptoms. Medical treatment is often effective in PD, but in general these are transitory. In this study, we tried to discriminate these groups by measuring tremor to use accelerometers. The measuring system was applied 38 subjects with PD (12), ET (15) and health elder (ll). Resting tremor with a frequency of 4-6Hz is a cardinal feature of PD, and postural tremor with a frequency of 6-8Hz is a typical feature of ET. Accordingly tremor recordings, with the subjects seated, were obtained while the subjects rested their hand on the desk (rest condition:about 15 sec), after posture changing, held both arms out stretched in front of them (postural condition : about 20 sec). Root-mean-square (RMS) of acceleration, each condition and frequency band, were compared PD with ET and control respectively. The ratio of RMS of acceleration on postural condition to RMS of acceleration on rest condition could significantly discriminate the PD (with resting tremor) from the other three types of tremor (p<0.0l) and the PD (without resting tremor) from ET (p<0.01). And RMS of acceleration on postural could significantly discriminate ET from the other two types of tremor (p<0.01). Besides the direction cosine component (level (-3)) on postural condition could significantly discriminate physiological tremor from pathologic tremor (p<0.0l). As the result, the technique will be useful for the diagnosis of tremor diseases.
長岡技術科学大学の論文
2000-12-27

姿勢変動時のウェーブレット変換を用いた振戦疾患鑑別手法の基礎研究

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