高張電解質水溶液による細胞損傷・死滅の反応速度論的モデル化(オーガナイズドセッション13 バイオシステムにおける熱・物質移動)

概要

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Process of cell damage and death due to the hypertonic electrolyte solution was modeled as a kind of reaction kinetic process. In our previous experiment, the cells were exposed from an isotonic solution (physiological saline) to a hypertonic electrolyte solution (concentration C_m and exposure time τ) back to the isotonic solution, and the cell viability was measured. An analytical solution with reaction rate constant determined by means of the inverse problem analysis had a good agreement to the cell viability obtained in the experiment. Also, the probability distribution, probability density function of cell death, and reaction kinetic properties were investigated. The result indicates that the cell damage and death proceeds similarly as a reaction kinetic process.
社団法人日本機械学会の論文
2004-11-10