スーパー抗原吸着カラムの有効性のグラム陽性菌敗血症モデル動物を用いた検討(<特集>新しい体外循環治療を学ぶ)

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Superantigens are suspected to be the potent and lethal pathogens of Gram-positive sepsis, and a new therapy that targets superantigens is required. To evaluate the efficacy of direct hemoadsorption for the removal of circulating superantigens, Gram-positive sepsis model animals were treated with a superantigen-adsorbing device (CYT 860). The mixed infection model was developed in rabbits by cecal ligation and puncture associated with the intraperitoneal injection of S. aureus, which produces toxic shock syndrome toxin-1. This model was hemoperfused with CYT 860 and the plasma levels of TSST-1 were significantly reduced (125pg/ml (CYT 860 group) vs. 186pg/ml (control group), at 4 hr after CLP, p<0.05) and shock-onset time was significantly retarded (Non-shock rate at 6 hr after CLP was 57% (CYT 860 group) vs. 100% (control group)). The multiple organ dysfunction model was developed in a Swan-Ganz catheter inserted pigs, by sequential infusion of TSST-1 and lipopolysaccharide. Hemoperfusion with CYT 860 resulted in an improvement of arterio-venous shunt ratio (7.1% (CYT 860 group) vs. 15.3% (control group) at 6 hr after TSST-1 infusion was initiated, p<0.05) and an improvement in the survival rate (66% (CYT 860 group) vs. 0% (control group) at 24 hr after TSST-1 infusion was initiated, p<0.05). It is suggested that there is a potential application of CYT 860 in treating superantigen-related sepsis and multiple organ dysfunctions.
日本アフェレシス学会の論文
2005-10-31

スーパー抗原吸着カラムの有効性のグラム陽性菌敗血症モデル動物を用いた検討(<特集>新しい体外循環治療を学ぶ)

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