フェムト秒レーザによる表皮下微細構造のin vivo高分解能OCTイメージング

概要

論文の詳細を見る
Optical coherence tomography (OCT) is very promising for high-resolution cross-sectional imaging underneath the surface of biological tissue. The axial resolution of OCT is determined by the coherence length of the light source used in a low-coherence interferometer. In this paper, we demonstrate high-resolution OCT of micro-tissue structures using a femtosecond Ti : sapphire laser. A coherence length of 3.1 μm is obtained using a bulk optic interferometer. In the experiment, micro-skin structures including the epidermis, dermis and stratum basale are clearly observed using high-resolution OCT. In vivo high-resolution OCT of human skin was also successfully demonstrated. Furthermore, the thickness of the stratum corneum can be measured as near as 20 μm using our OCT system. Our experimental results indicate that a femtosecond laser is suitable for high-resolution OCT for basic research in dermatology.
社団法人日本生体医工学会の論文
2004-12-10