ニフェジピン(Ca拮抗剤)による歯肉増殖症

概要

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We reported a case of gingival hyperplasia induced by administered nifedipine. The patient, a 61-year-old male with a history of hypertension, hyperlipemia and gout was treated with nifedipine 40 mg/day, pravastatin sodium 5 mg/kg and benzbromarone 50 mg/day by the internal medicine clinic for 1 year and 1 month. Gingival hyperplasia occurred in over 9 months after administration, and the patient visited our clinic with a chief complaint of gingival hyperplasia in 4 months later. Oral examination showed lobulated gingival hyperplasia of the nodular type in upper and lower jaws, but not in edentulous areas or around the remaining root portion. After the first examination, we immediately contacted the physician, who changed nifedipine to enalapril maleate. We performed gingivectomy and extracted tooth under general anesthesia after plaque control and scaling. We also performed relative alveolar crest shaping, because the vestibule of the mouth on upper and lower jaws was appeared flat. Histopathologically, the thick epithelial layer with elongation of rete ridges and proliferation of fibrous connective tissue were seen. There was chronic inflammatory infiltration in the fibrous connective tissue, but this was slightly beneath the epithelial layer.
福岡歯科大学学会の論文
1996-03-31