満洲において流行する家禽ペストに関する研究 : IV. 家禽ペスト継代ウィルスによる鶏中枢神経組織病変について

概要

論文の詳細を見る
In 1932 and 1938, one of the authors, YAMAGIWA, studied the histopathologicalchanges in the brain autd spinal cords of chickens infected naturally with fowl plaguein Manchuria. Moreover, he and his associates published three papers on experimentalwork with fowl plague passage virus. This paper deals with neurohistopathologicalinvestigation of the brain and spinal cord carried out on experimental cases with thefowl plague passage virus mentioned above.The materials and methods used in this study had been described in the previousreport, part 111.9) The viruses used were the Hoten A (A) and European strains (D).The chickens used were White Leghorn adults. Chicken brain emulsion containingthe virus was used as inoculum for chickens by the intramuscular route. Microscopicalexamination was performed on a total of 13 chickens. The experimental history ofthese birds was shown in Tables 2, 4, and 6 in the previous report, part [119).The basic histological changes were confined consistently to the ectodermal tissue,and composed mainly of focal microglial proliferation, which was occasionally accom-panied by a few oligodendroglial cells. The glial lesions were divided roughly intotwo groups, nodular foci (Fig. 4) and minute foci (Figs. 3, 6, 7, and 8). The formerwas well-defined, spherical in shape, and generally larger than the latter though vari-able in size. The latter was very minute in size and irregular in shape. A large numberof proliferated glial cells were arranged compactly in the former, but a few proliferatedglial cells were presented sparsely in the latter. It was difficult to find out whethertlae nodular foci were related to nerve cells, blood vessels, or non. On the other hand,the minute foci were often closely connectd with blood vessels, chiefly capillaries.There was a relationship between the occurrence of lesions and the inculated doseor virulent materials (Table 1). In cases given 10-2, 10-3, NO-4, and 10-5 g of brainmaterials, the lessions were predominantly large in number, while they were very small noticed. Changes in the mesenchymal tissue were scarcely observed in chicken inocu-lated experimentally with fowl plague passage virus. Some discussion, thereupon, wasmade on histogenesis in microglial reactions to viral infections.
社団法人日本獣医学会の論文
1970-10-25

満洲において流行する家禽ペストに関する研究 : IV. 家禽ペスト継代ウィルスによる鶏中枢神経組織病変について

スポンサーリンク

概要

著者

関連論文

スポンサーリンク