Biological Behavior of Dextran-Iron Oxide Magnetic Fluid Injected Intravenously in Rats
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概要
- 論文の詳細を見る
Dextran-magnetic iron oxide complex (CMDM) consisting of carboxymethyl dextran and a magnetite core has been synthesized. The physical and biological properties were compared with those of the conventional dextran-magnetite complex (ATDM). The CMDM exhibits a super-paramagnetic property, has high stability and low toxicity. The uptake and metabolic behavior of CMDM in live rats after intravenous (iv) administration were studied using pulsed nuclear magnetic resonance, optical microscopy and transmission electron microscopy. The ultrafine particles of CMDM were clearly observed in the lyso-somes of Kupffer cells in the liver and of macrophages in the spleen. The CMDM accumulated in the lysosomes was found to disappear within two weeks after the iv-injection. The results obtained in this work suggest that CMDM is appropriate for use as a contrast agent for magnetic resonance imaging (MRI).
- 社団法人応用物理学会の論文
- 1998-03-15
著者
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Kawaguchi Takeshi
Department Of Physics Faculty Of Science Shinshu University
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Shoji Hirokazu
Department Of Anesthesiology Jikei University Aoto Hospital
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Shoji Hirokazu
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Hanaichi Takamasa
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Maruno Shigeo
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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HASEGAWA Masakatsu
Department of Energy Science and Technology, Kyoto University
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Kawaguchi Takeshi
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Kawaguchi Takeshi
Department Of Applied Biological Chemistry College Of Agriculture University Of Osaka Prefecture
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Hasegawa Masakatsu
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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