Crystalglobulinemia with Fulminant Course with Cylinder-like Bodies on Peripheral Blood Smear
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概要
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A 63-year-old woman presented to our hospital with fever, purpura and pain in both legs and died 4 days after admission. Her blood smear and skin biopsy showed cylinder-like bodies (20×120 μm). She was diagnosed to have monoclonal gammopathy (IgG, lambda type). An autopsy revealed cylinder-like bodies in the vasculature of various organs. We noted a proliferation of atypical plasma cells in her bone marrow, suggesting pre-existing myeloma. Crystalglobulinemia is a rare manifestation of hypergammaglobulinemia that can cause multiple embolisms of the small vessels, and this resulted in the patient's fulminant course. The identification of cylinder-like bodies in the peripheral blood may help in reaching a diagnosis in such cases.
- 一般社団法人 日本内科学会の論文
著者
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UENO Shiro
Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, Unive
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Takajo Ichiro
Department Of Rheumatology Infectious Diseases And Laboratory Medicine Faculty Of Medicine Universit
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Kusumoto Norio
Department Of Internal Medicine Rheumatology Infectious Disease And Laboratory Medicine Faculty Of M
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Okayama Akihiko
Department Of Internal Medicine Ii Miyazaki Medical College
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Miyauchi Syunichi
Department Of Internal Medicine Rheumatology Infectious Disease And Laboratory Medicine Faculty Of M
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Kataoka Hiroaki
Section Of Oncopathology And Regenerative Biology Department Of Pathology Faculty Of Medicine Univer
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Nagatomo Yasuhiro
Department Of Internal Medicine Ii Miyazaki Medical College
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Kawaguchi Takeshi
Department Of Applied Biological Chemistry College Of Agriculture University Of Osaka Prefecture
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Yorita Kenji
Section Of Oncopathology And Regenerative Biology Department Of Pathology Faculty Of Medicine Univer
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Kariya Yumi
Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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Nagatomo Yasuhiro
Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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Matsuda Motohiro
Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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Kubo Kazuyoshi
Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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Tahira Yuki
Section of Oncopathology and Regenerative Biology, Faculty of Medicine, University of Miyazaki, Japan
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Yamamoto Syoko
Section of Oncopathology and Regenerative Biology, Faculty of Medicine, University of Miyazaki, Japan
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MATSUDA Motohiro
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital
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