火薬成分の毒性に関する研究 (その2) : ニトログリセリン(NG)とニトログリコロール(Ng)の冠循環及び心筋代謝に及ぼす影響についての実験的研究

概要

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Nitroglycol and nitroglycerine were injected subcutaneously to dogs in an amount of 0.5g per kg of the body weight, and a marked decrease of circulating blood amount in the coronary vessels with significantly lowered blood pressure were observed 10-20 minutes after the injection. In the heart muscle, decreases of oxygen consumption as well as its utilization and metabolic impairments of carbohydrates as well as fats occurred. Especially the last disorders were marked. No metabolic change was noticed as to K, Na, Cl, or Ca. Nearly similar changes were observed in the case in which 0.05g of the substance per kg of the body weight was injected at a time every week, but the impairment of fat metabolism was more severe, being suppressed almost to nil. Therefore, decrease of cardiac function caused by nitroglycerine and nitroglycol are thought to be due to impairment of coronary circulation and of gas exchange as well as carbohydrate and fat metabolisms in the cardiac muscle.
社団法人日本産業衛生学会の論文
1962-10-20