Acceptability and Long-Term Compliance with Drug Treatment for Hypercholesterolemia in Japanese Male Workers : I. Acceptability of Drug Treatment

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概要

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• We performed a prospective study to assess the acceptability and long-term compliance with drug treatment for hypercholesterolemia in Japanese male workers aged 40 to 57 yr with hypercholesterolemia detected in legally required periodical physical examinations. This paper describes the acceptability of statin-based drug treatment. All eligible workers who had not improved after 3-month diet therapy were recommended for drug treatment with simvastatin, a 3 hydroxy-3-methylcoenzyme A reductase inhibitor. Subsequently, according to each individual preference, the subjects were divided to two groups: a group which accepted drug treatment (DT) and a group which rejected it. The subjects who did not accept drug treatment were further assigned to two groups according to their preference: a group which accepted only dietary intervention (Dl) and a non-treatment group (NT). Among 1,278 workers recruited, 656 (51.3%) were placed in the DT group, 414 (32.4%) in the Dl group and 208(16.3%) in the NT group. In the DT group, mean serum total cholesterol (TO) was the highest [272 ± 30 (SD) mg/d/]. The acceptability of drug treatment was significantly associated with the serum TO level, pre-existing medical history of hypertension and a family history of ischemic heart disease (IHD). The occupational issues such as type of job, overtime worked, sleeping time and psychological status were different among the three groups, and habits of taking breakfast and daily exercise were associated with acceptability of drug treatment. These data suggest that acceptability of the drug treatment is low and associated with the work-and lifestyle- related issues as well as IHD risk factors.

著者

• YOSHIDA Katsumi

  Department of Clinical and Laboratory Medicine, Tohoku University School of Medicine

• Okubo Yasushi

  Health Care Center University Of Tokyo

• Okubo Y

  Department Of Occupational And Environmental Medicine Chiba University School Of Medicine:s-lit Stud

• Okubo Yasushi

  Health Care Center Univ. Of Tokyo

• SUGIMORI Hiroki

  Depart. of Hygiene & Preventive Medicine, Showa University School of Medicine

• Nakatani Atsushi

  Hitachi hearth Care Center

• Sugimori Hiroki

  Department Of Preventive Medicine St. Marianna University School Of Medicine:s-lit Study Group

• HAYASHI Takeshi

  HITACHI Information & Telecommunication Systems Shinkawasaki Health Care Center

• HIRO Hisanori

  Adecco Health Support Center

• HAMAGUCHI Tsutahiro

  IBM Japan Medical Services

• HASHIRA Munetaka

  Health Management Division of Aizuwakamatsu Factory, Fujitsu Corp.

• ITO Masato

  Health Management Division of Matsushita Electronics Corp.

• HIRO Hisanori

  Center for Occupational Health, Tsurum, NKK.

• MORI Koji

  Medicine & Occupational Health, Exxon Mobil Business Services Private Ltd

• EZAKI Takafumi

  Kyoto Industrial Health Association

• TATEMICHI Masayuki

  Department of Environmental and Occupational Health, Toho University School of Medicine

• OOKUBO Yasushi

  Department of Occupational and Environmental Medicine Chiba University School of Medicine

• Nakatani Atsushi

  Hitachi Health Care Center:s-lit Study Group

• Mori K

  Univ. Occupational And Environmental Health Jpn

• Hiro Hisanori

  Center For Occupational Health Tsurumi Nkk Corporation Tsurumi Works

• Ezaki Takafumi

  Kyoto Industrial Health Association:s-lit Study Group

• Tatemich Masayuki

  Department Of Environmental And Occupational Health Toho University School Of Medicine:s-lit Study G

• Tatemichi Masayuki

  Department Of Environmental And Occupational Health Toho University School Of Medicine

• Ezaki Takafumi

  Kyoto Industrial Health Assoc. Kyoto Jpn

• Hashira Munetaka

  Health Management Division Of Aizuwakamatsu Factory Fujitsu Corp.:s-lit Study Group

• Hamaguchi Tsutahiro

  Ibm Japan Medical Services:s-lit Study Group

• Yoshida Katsumi

  Department Of Preventive Medicine St. Marianna University School Of Medicine:s-lit Study Group

• Mori Koji

  Medical Services Department Esso Sekiyu K.k.

• Ito Masato

  Health Management Division Of Matsushita Electronics Corp.:s-lit Study Group

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