Acceptability and Long-Term Compliance with Drug Treatment for Hypercholesterolemia in Japanese Male Workers : II. Long-Term Compliance with Drug Treatment

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概要

• 論文の詳細を見る

• We undertook a prospective study to assess the long-term compliance of Japanese male workers with drug treatment for hypercholesterolemia. In workers who accepted treatment with simvastatin, an HMG-CoA reductase inhibitor, compliance was monitored every 6 months with an interview. Factors affecting compliance were identified by using the background characteristics of subjects and a self-administered questionnaire on their type of job, job style, private lifestyle and psychological status at work. Mean (SD) follow-up periods were 21.5 (10.6) months for 640 workers, and 240 noncompliant (<75 % of prescription) subjects were found. Of these 240, 23 (9.6%) were restored to be finally compliant at the last follow-up (re-compliant). We assessed the time-course rate of compliant subjects and factors affecting drug compliance using Cox proportional hazard model by setting occurrence of a noncompliant attitude to an endpoint. The cumulative compliance rate at 36 months was 0.508 when excluding 23 re-compliant subjects and 0.529 when considering them as compliant. Multivariate analysis showed that age and present medical illness with hypertension (HT) in background characteristics of subjects and the habit of having breakfast daily in factors related to private-lifestyle were significantly associated with compliance. Baseline lipid profiles and work related issues were not associated with compliance. The occurrence rate of side effects did was similar in compliant and noncompliant workers. In this study, even though considering the re-compliant subjects, the rate of compliant subjects over a 3-yr period was considerably low (around 50%). The factors related to compliance were age, present illness with HT and the habit of having breakfast daily.

• 社団法人日本産業衛生学会の論文

著者

• OKUBO Yasushi

  Department of Hygiene, Chiba University School of Medicine

• YOSHIDA Katsumi

  Department of Clinical and Laboratory Medicine, Tohoku University School of Medicine

• Okubo Yasushi

  Health Care Center University Of Tokyo

• Okubo Y

  Department Of Occupational And Environmental Medicine Chiba University School Of Medicine:s-lit Stud

• Okubo Yasushi

  Health Care Center Univ. Of Tokyo

• SUGIMORI Hiroki

  Depart. of Hygiene & Preventive Medicine, Showa University School of Medicine

• Nakatani Atsushi

  Hitachi hearth Care Center

• Sugimori Hiroki

  Department Of Preventive Medicine St. Marianna University School Of Medicine:s-lit Study Group

• HAYASHI Takeshi

  HITACHI Information & Telecommunication Systems Shinkawasaki Health Care Center

• HIRO Hisanori

  Adecco Health Support Center

• TATEMICH Masayuki

  Department of Environmental and Occupational Health, Toho University School of Medicine

• HAMAGUCHI Tsutahiro

  IBM Japan Medical Services

• HASHIRA Munetaka

  Health Management Division of Aizuwakamatsu Factory, Fujitsu Corp.

• ITO Masato

  Health Management Division of Matsushita Electronics Corp.

• HIRO Hisanori

  Center for Occupational Health, Tsurum, NKK.

• MORI Koji

  Medicine & Occupational Health, Exxon Mobil Business Services Private Ltd

• EZAKI Takafumi

  Kyoto Industrial Health Association

• Nakatani Atsushi

  Hitachi Health Care Center:s-lit Study Group

• Mori K

  Univ. Occupational And Environmental Health Jpn

• Hiro Hisanori

  Center For Occupational Health Tsurumi Nkk Corporation Tsurumi Works

• Ezaki Takafumi

  Kyoto Industrial Health Association:s-lit Study Group

• Tatemich Masayuki

  Department Of Environmental And Occupational Health Toho University School Of Medicine:s-lit Study G

• Tatemichi Masayuki

  Department Of Environmental And Occupational Health Toho University School Of Medicine

• Ezaki Takafumi

  Kyoto Industrial Health Assoc. Kyoto Jpn

• Hashira Munetaka

  Health Management Division Of Aizuwakamatsu Factory Fujitsu Corp.:s-lit Study Group

• Hamaguchi Tsutahiro

  Ibm Japan Medical Services:s-lit Study Group

• Yoshida Katsumi

  Department Of Preventive Medicine St. Marianna University School Of Medicine:s-lit Study Group

• Mori Koji

  Medical Services Department Esso Sekiyu K.k.

• Ito Masato

  Health Management Division Of Matsushita Electronics Corp.:s-lit Study Group

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