In Vitro Metabolism of Testosterone Sulfate and Testosterone Tetrahydropyranyl Ether in Male Rat Liver
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概要
- 論文の詳細を見る
In vitro metabolism of ^3H-testosterone 17-sulfate (^3H-TS) and ^<14>C-testosterone 17-tetrahydropyranyl ether (^<14>C-TP) was studied by incubation with 20000×g or 105000×g supernatant and microsomal fractions of male rat liver homogenate under carbon monoxide atmosphere or in air. The results demonstrated that the steroidal ring A of ^3H-TS was readily metabolized by microsomal Δ^4-5α-hydrogenase, while ^<14>C-TP was a good substrate for Δ^4-5β-hydrogenase present in the 105000×g supernatant fraction as well as microsomal Δ^4-5α-hydrogenase. On the other hand, ^3H-TS and ^<14>C-TP were not good substrates for microsomal hydroxylases. The influence of the substituent at C-17 of testosterone upon the biotransformation of ring A was discussed.
- 公益社団法人日本薬学会の論文
- 1973-03-25
著者
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岡田 正志
Tokyo Biochemical Research Institute
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松井 道夫
Tokyo Biochemical Research Institute
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安倍 福雄
Tokyo Biochemical Research Institute
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國包 みどり
Tokyo Biochemical Research Institute
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岡田 正志
(財)東京生化学研究会
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