Preparation of Ring A-Modified Cardenolides
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概要
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Preparation of several ring A-modified cardenolides from digitoxigenin is presented. 3,5-Seco-4-nor-cardenolides were prepared by oxidative cleavage of the ring A of the 3-oxo-Δ^4-derivative with ruthenium tetroxide and 4-oxa-cardenolides were derived from the 3,5-seco-4-nor-cardenolide. The structure-activity relationship in these ring A-modified cardenolides is discussed.
- 公益社団法人日本薬学会の論文
- 1977-11-25
著者
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岡田 正志
Tokyo Biochemical Research Institute
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岡田 正志
(財)東京生化学研究会
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安生 孝子
Tokyo biochemical Research Institute
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