14,15-cis Glycols derived from Digitoxigenin
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概要
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Treatment of β-anhydrodigitoxigenin acetate (I) with osmium tetroxide gave two cis-glycols (β- and α-), 15β-hydroxydigitoxigenin 3-monoacetate (II) and 15α-hydroxy-14α-digitoxigenin 3-monoacetate (IV) in the ratio of approximately 1 : 9. Acid hydrolysis of II and IV yielded 15β-hydroxydigitoxigenin (III) and 15α-hydroxy-14α-digitoxigenin (V). On the other hand, treatment of β-anhydro-17α-digitoxigenin (β-anhydromenabegenin) (X) as well as its acetate (IX) with the reagent resulted exclusively in the formation of the β-glycol, 15β-hydroxy-17α-digitoxigenin (15β-hydroxymenabegenin) (XII) and its 3-monoacetate (XI) respectively.
- 公益社団法人日本薬学会の論文
- 1969-03-25
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