Studies on Synthesis of Epoxides of Anhydrocardenolides and on Their Cleavage. II. Synthesis of Epoxides of Anhydrogitoxigenins and Their Cleavage.
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概要
- 論文の詳細を見る
Epoxidation of Δ^<14,16>-dianhydrogitoxigenin (I) with 1.2 molar equivalents of perbenzoic acid gave 3β-hydroxy-14β, 15β-epoxy-5β-carda-16,20 (22)-dienolide (III) which was hydrogenated over palladium-on-charcoal to afford 17α-digitoxigenin and digitoxigenin, both being obtained and identified as their acetates (IX, X). The preparation of 3β, 16β-diacetoxy-14α, 15α-epoxy-5β-carda-16,20 (22)-dienolide (XII) from Δ^<14>-anhydrogitoxigenin diacetate (XI) and some reactions of XII were described.
- 公益社団法人日本薬学会の論文
- 1966-05-25
著者
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岡田 正志
Tokyo Biochemical Research Institute
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斉藤 行生
Tokyo Biochemical Research Institute
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山田 厚
Tokyo Biochemical Research Institute
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蓮沼 美恵子
Tokyo Biochemical Research Institute
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岡田 正志
(財)東京生化学研究会
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