IDENTIFICATION OF A MOUSE SERUM PROTEIN INCREASED BY ADMINISTRATION OF AN ANTITUMOR POLYSACCHARIDE, PSK, AS A VARIANT OF MOUSE TRANSFERRIN AND SOME OF ITS BIOLOGICAL ACTIVITIES

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概要

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• One of the so-called LC components, the content of which is increased in the serum of PSK (antitumor polysaccharide) treated mice, was purified by repeated ionexchange column chromatography on DEAE-Sephadex A-50. The purified protein, designated as LC-2,was identified as a variant of mouse transferrin, which is a serum β_1-globulin having an iron-binding capacity. The absorption spectrum and ultraviolet circular dichroism (CD) curve of LC-2 were identical with those of mouse transferrin. The molecular weight, isoelectric point and amino acid composition of LC-2 were in good agreement with the results obtained previously for mouse transferrin. However, the carbohydrate content of LC-2 was different from that of mouse transferrin. This protein restored the depressed spleen cell response of tumor-bearing mice to concanavalin A (Con A) and promoted the metabolism of proteose-peptone induced peritoneal macrophages obtained from tumor-bearing mice. Furthermore, it had weak but definite antitumor activity against Sarcoma 180 cells in vivo.

• 公益社団法人日本薬学会の論文

著者

• 児島 英介

  Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of

• MITSUNO TOHRU

  Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University

• KOJIMA EISUKE

  Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University

• OSAWA TOSHIAKI

  Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University

• Osawa Toshiaki

  Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of

• Osawa Toshiaki

  Laboratory Of Molecular Medicine Department Of Integrated Biosciences Graduate School Of Frontier Sc

• Kojima Eisuke

  Division Of Chemical Toxicology Immunochemistry Faculty Of Pharmaceutical Sciences University Of Tok

• Mitsuno Tohru

  Division Of Chemical Toxicology Immunochemistry Faculty Of Pharmaceutical Sciences University Of Tok

• OSAWA Toshiaki

  Yakult Central Institute for Microbiological Research

• Osawa Toshiaki

  Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Science University Of

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