ELEVATION OF COLONY STIMULATING FACTORS IN MOUSE SERUM AFTER INJECTION OF PSK, AN ANTITUMOR POLYSACCHARIDE
スポンサーリンク
概要
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The level of colony stimulating factors (CSF) in mouse serum was elevated by a single intrapertoneal injection of PSK, a host-mediated antitumor protein-bound polysaccharide obtained from Basidiomycetes. The assay for CSF activity was performed by employing a semisolid methylcellulose culture method using mouse bone marrow cells, and the activity was estimated by an equation well matched with the dose response curve obtained in the CSF assay. A temporary increase of CSF activity within 10 h after the injection of an antitumor polysaccharide, Krestin (PSK) (250-1000 mg/kg) was followed by a fast decline in the activity, but no significant increases were detected in cases of 62.5 and 125 mg/kg PSK injection. The CSF activity in PSK (500 mg/kg)-treated mouse serum was separated into two active fractions by DEAE ion-exchange chromatography, and both fractions were found to induce colonies comprised of cells with the properties of macrophage in regard to morphology, cytochemistry of non-specific esterase, phagocytic function and expression of Fc receptors on the cell surface. The elevation of the serum CSF level due to administration of socalled host-mediated antitumor agents might be one of the tumor-defense mechanisms in vivo.
- 公益社団法人日本薬学会の論文
著者
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児島 英介
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of
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Satoh Motonobu
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of
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ICHIMURA OSAMU
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University
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MITSUNO TOHRU
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University
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KOJIMA EISUKE
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University
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OSAWA TOSHIAKI
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University
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Osawa Toshiaki
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of
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Osawa Toshiaki
Laboratory Of Molecular Medicine Department Of Integrated Biosciences Graduate School Of Frontier Sc
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Kojima Eisuke
Division Of Chemical Toxicology Immunochemistry Faculty Of Pharmaceutical Sciences University Of Tok
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Mitsuno Tohru
Division Of Chemical Toxicology Immunochemistry Faculty Of Pharmaceutical Sciences University Of Tok
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Ichimura Osamu
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of
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OSAWA Toshiaki
Yakult Central Institute for Microbiological Research
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Osawa Toshiaki
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Science University Of
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