EFFECT OF A MONOCLONAL ANTI-CARCINOEMBRYONIC ANTIGEN ANTIBODY-RICIN A-CHAIN CONJUGATE ON HUMAN CARCINOEMBRYONIC ANTIGEN-PRODUCING TUMOR CELLS
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概要
- 論文の詳細を見る
For the development of therapeutic agents that are coupled to tumor specific cariers, an artificial protein hybrid conjugate (immunotoxin) containing monoclonal anticarcinoembryonic antigen (CEA) antibody which binds specifically to the cell surface of CEA-producing tumor cells and a toxic subunit of ricin (A-chain) was prepared. This conjugate exerted strong cytotoxicity specifically toward CEA-producing tumor cells in vitro. In vivo, it has anti-tumor effects on ascitic tumor cells, and on free tumor cells before the solid tumor has been established. However, for the established solid tumor, a significant decrease of tumor growth was not seen even after repeated intravenous administrations of the antibody-ricin A-chain conjugate. Furthermore, the conjugate was found to be stable in both mouse and human serum in vitro, but after intravenous injection, it was inactivated in vivo quickly.
- 公益社団法人日本薬学会の論文
著者
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Miyazaki Hiroshi
Division of Bioengineering, Graduate School of Engineering Science, Osaka University
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WATANABE Yoshifumi
Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University School of Medicine
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Watanabe Yoshifumi
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of
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OSAWA TOSHIAKI
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University
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Osawa Toshiaki
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of
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Osawa Toshiaki
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Science University Of
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Miyazaki Hiroshi
Division Of Bioengineering Department Of Mechanical Science And Bioengineering Graduate School Of En
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Miyazaki Hiroshi
Division Of Chemical Toxicology And Immunochemistry Faculty Of Pharmaceutical Sciences University Of
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