Simultaneous monitoring of electrochemical and unitary neuronal activities by a single carbon fiber microelectrode.
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概要
- 論文の詳細を見る
Simultaneous measurements of electrochemical and electrophysiological changes in the substantia nigra pars compacta of the rat were tried with a single carbon fiber microelectrode. Electrochemical detection of catecholamines was done by differential pulse voltammetry. The effects of haloperidol on the level of catecholamines in extracellular spaces and on dopaminergic neuronal discharges were investigated. Haloperidol induced an increase in unitary discharges parallel to the elevation of the catecholamine level. With this technique, direct information can be obtained on the relationship between released catecholamines and unitary neuronal activity.
- 公益社団法人 日本薬理学会の論文
著者
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IKEDA Masato
Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Med
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Miyazaki Hiroshi
Division Of Bioengineering Department Of Mechanical Science And Bioengineering Graduate School Of En
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MATSUSHITA Akira
Division of Pharmacology, Shionogi Research Laboratories, Shionogi & Co., Ltd.
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MIYAZAKI Hiroshi
Division of Pharmacology, Shionogi Research Laboratories, Shionogi and Co., Ltd.
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