High Vacuum Silicone Greaseによる医薬品, 食品添加物などのガスクロマトグラフ的分析(I) : 医薬品のガスクロマトグラフ的活性, 不活性について

概要

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Gas chromatographic analyses of drugs and food additives have been reported by many authors. Experimental conditions, especially the selection of stationary phase, however, have been selected only empirically, and the theoretical considerations on these selections seem useless to be applied in practice. Considering the purpose of this instrument, it is preferable to use a few kind of staitionary phases. In order to know the effectiveness of a stationary phase, high vacuum silicone grease, for the separation of drugs, gas chromatographic analysis of 20 drugs were carried out with the same experimental condition. Acetanilide, ethyl aminobenzoate, phenacetin, caffeine, aminopyrine, antipyrine, barbital, chlorpheniramine maleate, santonin, testosterone, and diethylstilbestrol were separated satisfactorily, whereas quinine hydrochloride and quinine sulfate were not detected. Variation in results was observed with different lot of the stationary phase, but the good results were obtained with a suitably aged column. Introduction of 200〜300 mg of the sample were proved to be appropriate. Consequently, in order to obtain good and reproducible results, stationary phase must be selected with respect to its kind as well as to its aged state otherwise reproducibility in results could not be expected.
公益社団法人日本薬学会の論文