ビタミンB_1類の安定性に関する研究(第11報) : 酸性水溶液中のO, S-Bis (alkoxycarbonyl) thiaminesの安定性

概要

論文の詳細を見る
Analysis with an analog computer was made on the degradation of O, S-bis (ethoxycarbonyl) thiamine (I) in aqueous solution at 100° in a pH range from of 1 to 5. The analyses were based on both the results of the separate determination of the degradation products including thiamine (B_1), O-ethoxycarbonylthiamine (II), S-ethoxycarbonyl thiamine (V), 2-methyl-4-amino-5-hydroxymethylpyrimidine (III), and 2-methyl-4-amino-5-aminomethylpyrimidine (IV), and on the results previously reported for the degradation of II and V. Four different degradation routes of I were found : the two first ones are hydrolyses of -O-COOC_2H_5 and -S-COOC_2H_5 to -OH and -SH, respectively, and the other two are direct formations from I to III and to IV. At lower pH values, below or around 1.5,the reaction I→IV proceeded more easily than the other reactions and the reaction I→V was faster than the reaction I→II, where the product V was further converted to II. At the higher pH values, however, the rate of the reaction I→V was small compared with the overall degradation rate of I, and -S-COOC_2H_5 of I was hydrolysed faster than -O-COOC_2H_5 of I. These results are supported because we found relative amounts of two different O-alkoxycarbonylthiamines (B_1-O-COOR_1 and B_1-O-COOR_2) produced from O, S-bis (alkoxycarbonyl) thiamines (R_1-OOC-O-B_1-S-COOR_2). Furthermore, the stability of I was compared with the stabilities of fifteen different B_1 derivatives of acyl, a1koxycarbonyl, and disulfide types in aqueous solutions under the conditions mentioned above.
社団法人日本薬学会の論文
1969-03-25

ビタミンB_1類の安定性に関する研究(第11報) : 酸性水溶液中のO, S-Bis (alkoxycarbonyl) thiaminesの安定性

スポンサーリンク

概要

著者

関連論文

スポンサーリンク