セファロチンナトリウムの凍結相における結晶成長(第2報)種晶量, 濃度及び温度の影響

概要

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The growth rate of cephalothin sodium (KF) after seeding in frozen solution was measured. Crystal growth of KF followed equation (1) untill α=0.98. 1-(1-α)^<1/3>=(1/3N) (Kt)^N……(1) where α is crystallinity, K is rate constant, t is time, and N is parameter depending on the freezing temperature and the amount of seed. Crystal growth of KF in the frozen solution hardly changed when the concentration of KF was in the range of 19.4% to 28.6% but it was remarkably dependent on the amount of seed at the constant freezing temperature. According to the decrease in the amount of seed at the constant freezing temperature, the value of N increased and the rate constant (K) decreased. The growth rate increased with a rise of freezing temperature, and had the maximum value at a temperature little below the eutectic temperature. The activation energy of crystal growth of KF in the range of -5℃ to -14℃ was 49 kcal/mol.
公益社団法人日本薬学会の論文
1984-12-25