合成高分子化合物と医薬品との相互作用に関する研究(第1報) : スチレン無水マレイン酸共重合体とチアミン誘導体との相互作用

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The interaction between some thiamine derivatives and styrene-maleic anhydride copolymer(SMA) was studied. Ultraviolet absorption measurements on the mixed solutions of O, S-bis(ethoxycarbonyl)thiamine, thiamine tetrahydrofurfuryldisulfide, and pyrimidine derivatives with SMA indicate the presence of donor-acceptor type binding between acid anhydride group in the SMA and pyrimidine group in the thiamine derivatives. The interaction of the following six thiamine derivatives of thiol type with SMA was also examined through a distribution method at 25° and 37° : O, S-bis(benzoyl)thiamine disulfide, O, S-bis(ethoxycarbonyl)thiamine, S-ethoxycarbonylthiamine, S-butoxycarbonylthiamine, O-benzoylthiamine, and thiamine tetrahydrofurfuryldisulfide. It was found that these derivatives show a strong affinity to SMA, and that the binding process is a Langmuir-type relationship. The temperature dependence of the binding showed a decrease in binding constant with increase in the temperature from 25° to 37°. The maximum amount of each derivative bound to SMA was found to be 0.2 to 0.3 mmole/g, regardless of the temperature, and each value for O, S-disubstituted derivatives was smaller than that for S-monosubstituted derivatives. Each amount thus obtained also indicated that one thiamine derivative molecule was bound by about 10 monomeric units of the copolymer chain. The significance of these results was discussed in relation to a possible binding mechanism.
社団法人日本薬学会の論文
1969-11-25

合成高分子化合物と医薬品との相互作用に関する研究(第1報) : スチレン無水マレイン酸共重合体とチアミン誘導体との相互作用

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