漢薬甘遂の成分研究(第8報) : Euphol, Tirucallolおよびβ-EuphorbolのKMnO_4酸化

概要

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Permanganate oxidation of euphol (I), tirucallol (XII), and β-euphorbol was examined. Permanganate oxidation of I in acetone afforded colorless needles (III), m.p. 224〜225°, C_<27>H_<44>O_3,while the same oxidation of β-euphorbol gave yellow needles (VI), m.p. 218〜220°, C_<27>H_<40>O_5,besides III. Further oxidation of III with chronic acid in glacial acetic acid afforded yellow needles (VIII), m.p. 178°, C_<27>H_<38>O_5. Permanganate oxidation of I in glacial acetic acid afforded VIII, which was also obtained by the same oxidation of β-euphorbol. The same oxidation of XII gives yellow needles (XIII), (efferv. with decomp. at around 215°), C_<27>H_<40>O_5. From the nature of the so-called β-euphorbol, it was considered to be a mixed crystal or molecular compound of I and an aldehyde of C_<10> to C_<12>.
公益社団法人日本薬学会の論文
1967-01-25