酵母細胞壁の抗腫瘍作用の免疫学的解析(第1報)抗腫瘍作用の検討および免疫抑制の影響

概要

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Yeast cell wall (YCW) or its polysaccharide (glucan), when inoculated subcutaneously as a mixture with Ehrlich ascites tumor cells into mice, remarkably suppressed the tumor growth at the injected site. However, both water-solubilized (enzyme digested) glucan and mannan obtained from YCW were difficult to show effective suppression on the tumor growth. Tumor suppressive effect of YCW in mice was markedly diminished by previous treatment of mice with either anti-thymocyte serum (ATS) or X-ray irradiation. Weeks after the inoculation of YCW-tumor cell mixture, these mice showed high resistance to growth of the same tumor cells, if reinoculated. Thus, these mice were termed"tumorsuppressed mice."Higher doses (800-900 R) of irradiation or ATS administration to the"tumor-suppressed mice"could completely abolish their resistance to the tumor cells, while low doses (400-500 R) of irradiation could still preserve their ability to inhibit the tumor growth to some extent. Neutralizing test in vivo revealed that the sensitized lymphocytes obtained from the mice which had been inoculated with YCW-tumor cell mixture several weeks in advance had some ability to suppress the growth of inoculated tumor cells. These results suggest that both phenomena, the tumor suppressive effect of YCW and the growth inhibitory effect in"tumor-suppressed mice"are related to the immunological capability of the host.
公益社団法人日本薬学会の論文
1978-08-25