Mitogenicity and Adjuvanticity of Lipopolysaccharide from a Marine Bacterium, Vibrio anguillarum, in Mice

概要

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The effects of lipopolysaccharides (LPS) extracted from three O-serotype (A, B, and C) strains of Vibrio anguillarum on the murine immune response were studied. Although the LPSs lack 2-keto-3-deoxyoctonate (KDO) and the sugar compositions of their core regions are markedly different, depending on the O-serotype, they were all able to induce a mitogenic effect on in vitro-cultured spleen cells of C57BL/6 mice. The LPS was capable of increasing the incorporation of ^3H-thymidine into spleen cells that had been treated with rabbit antithymocyte serum in the presence of complement in order to kill T-lymphocytes. When sheep erythrocytes and LPS were injected intraperitoneally into BALB/c mice, the LPSs exhibited an enhancing effect on the antibody response regardless of the serotype. These findings suggest that these biological effects of V. anguillarum LPSs from different O-serotype strains are little affected by the absence of KDO and the differences in sugar composition.
社団法人日本薬学会の論文
1984-10-25