酵母細胞壁の抗腫瘍作用の免疫学的解析(第2報)マウスリンパ球におよぼす酵母細胞壁の影響
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概要
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To investigate the role of lymphocytes on the antitumor activity of yeast cell wall (YCW) in mice, functional analysis of lymphocytes was made on the basis of the mitogenic response (^3H-thymidine uptake) of mouse spleen cells to bacterial lipopolysaccharide (LPS ; a B cell mitogen) and Concanavalin A (Con A ; a T-cell mitogen). When normal mice and"tumor suppressed mice"(the mice in which tumor growth had been suppressed by the mixed injection of YCW and Ehrlich ascites tumor cells : EATC) were administered anti-thymocyte serum (ATS) or irradiated with X-rays, the tumor suppressive effect of YCW and their acquired resistance against tumor transplantation decreased. By the administration of ATS into these mice, the response of their spleen cells to Con A was reduced, but the response to LPS was not. X-Ray irradiation resulted in the reduction of mitogenic responses to both Con A and LPS. These results suggest that the tumor suppressive effect of YCW is mediated by T-cell function in mice and the acquired tumor resistance is also dependent on their T-cell function. The mitogenic activity of YCW was confirmed on cultured spleen cells in vitro. The spleen cells from the mice 2 days after the administration of YCW showed a marked enhancement of the mitogenic response to LPS. This fact indicates that YCW is capable of increasing B-cell population and/or the mitogenic responsiveness of B-cells in mouse spleen. The change of mitogenic response of spleen cells to LPS, Con A and Mitomycin-C treated EATC (MMC-EATC) during process of tumor suppression after the injection of mixture of YCW and EATC were investigated. Two days after the injection, the enhancement of mitogenic responses to LPS and MMC-EATC were observed. On 28 days, when the growth of tumor was mostly suppressed, the mitogenic response of their spleen cells to Con A was incresed. These finding suggest that YCW stimulates the B-cell at the early stage after the injection, and then converts its stimulation into T-cell in the advanced stage. The enhancement of T-cell function in the advanced stage be YCW may relate to its ability on anti-tumor activity.
- 公益社団法人日本薬学会の論文
- 1978-08-25
著者
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清水 忠順
静岡薬科大学
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三渕 一二
静岡薬科大学
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清水 忠順
Department Of Microbiology School Of Pharmaceutical Sciences University Of Shizuoka
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原口 惣一
静岡薬科大学
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