5-Oxothiazolidine-2-thione誘導体並びにRhodanine誘導体の抗菌性について

概要

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A number of phenylacrolein, furylacrolein, benzaldehyde and furfural derivatives, including their α-bromides, were synthesized. Further, their condensation products with rhodanines and 5-oxothiazolidine-2-thione were synthesized. The in vitro antimicrobial activity of these compounds (76 compounds in all) was also determined. 1) Introduction of bromine into α-position of these compounds, particularly in a series of phenylacrolein derivatives, and of NO_2 group into 5-position of the furylacrolein derivatives significantly increased the antimicrobial activity. 2) Some benzylidene derivatives of rhodanines and of 5-oxothiazolidine-2-thione were found to be active against Trichophyton, whereas those of phenylacrylidene derivatives were found to be inactive.
公益社団法人日本薬学会の論文
1972-04-25