Nafamstat Mesilateの水溶液中での安定性に関する研究(第1報)各種pH及び温度条件下における反応の動力学的検討

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Kinetics of nafamstat mesilate in aqueous solution was studied and the following findings were obtained. In aqueous solution, nafamstat mesilate was exclusively hydrolyzed to form its moieties of 4-guanidinobenzoic acid and 6-amidino-2-naphthol. The hydrolysis followed a pseudo-first order reaction and was catalyzed by each hydrogen ion, hydroxyl ion and water depending on the pH conditions in the pH range of 1-7,the following the kinetic law of k_0=k_Hα_H+k_<H_2O>+k_<OH>α_<OH>. In the pH range of 3-9,the buffer concentration effect was observed. The ionic strength effect at pH 1 and 9 among pH 1,3 and 9 studies was also observed. Nafamstat mesilate was most stable under acidic conditions, i.e. at pH 3.29 and 3.21 at 50℃ and 60℃, respectively, as shown by pH-rate profile.
公益社団法人日本薬学会の論文
1985-05-25