D-Arabinosoneの酵素化学的研究(第6報) : Escherichia coliの増殖におよぼすOsoneの影響

概要

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The effect of osones, especially of D-arabinosone, on the growth of Escherichia coli (E. coli) was examined and the following results were obtained. 1) D-Arabinosone, D-xylosone, L-arabinosone, D-glucosone, and triosone showed an inhibitory effect on the growth. Pentosones showed bacteriostatic inhibition, but triosone showed bactericidal inhibition. D-Glucosone seemed to be utilized as a carbon source. 2) The inhibitory effect of D-arabinosone was apparent in resting cells. 3) The inhibition of growth by D-arabinosone was readily abolished by the addition of D-ribose, while the inhibition by D-xylosone and by L-arabinosone was readily abolished by the addition of sulfhydryl compounds. 4) D-Arabinosone had only a small effect on the growth of E. coli in the medium containing D-ribose as a carbon source. 5) The oxidation of D-glucose with intact cells was inhibited by D-arabinosone, but that with cell-free extract was not inhibited. 6) The utilization of D-glucose by intact cells was inhibited by D-arabinosone, but that of D-ribose was not inhibited. From these results, it is concluded that the inhibition of growth of E. coli by D-arabinosone is not the same as the inhibition by other osones studied, and a major factor in the inhibition by D-arabinosone is suggested to be an interference of the transport of D-glucose into the cells by D-arabinosone, though the transport of D-ribose is not interfered.
社団法人日本薬学会の論文
1971-09-25