各種分子量を有するXylitol-Iron-Citrate Complex の調製ならびにそれらComplex筋肉内注射時の鉄血中濃度および尿中排泄に対する分子量の影響

概要

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Various xylitol-iron-citrate complexes were prepared by addition of 0.15 molar ratio of sodium citrate to iron (III) to the xylitol-iron complexes, which were obtained by the static hydrolysis of aqueous solution of ferric chloride hexahydrate with Amberlite IRA-410 (OH type) in the presence of 0-1.42 molar ratio of xylitol to iron (III) (X1/Fe). Particle properties of the xylitol-iron-citrate complexes, plasma iron level, and urinary excretion of iron following intramuscular administration of the complexes were examined. (1) Sedimentation constant of the complexes decreased with augmentation of X1/Fe as follows : X1/Fe=0 : 21.6S, X1/Fe=0.36 : 7.2S, X1/Fe=0.71-1.42 : 4.0-4.7S. (2) There was a tendency for the maximum iron level in plasma and urinary excretion of iron to increase during the first 24 hr after application with decreasing molecular weight of the complexes.
社団法人日本薬学会の論文
1971-12-25