鉄の腸管吸収に関する研究(第1報)鉄塩の加水分解重合に対する糖, 多価アルコールおよび有機酸の影響

概要

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Effect of glucose, fructose, sorbitol, xylitol, citric acid, and gluconic acid on hydrolytic polymerization of iron was examined. 1) Fructose, sorbitol, or xylitol (20 mM each) added to 1 mM ferric chloride solution inhibited the polymerization of iron during alkaline hydrolysis process and gave a low molecular polymer. These facts were confirmed by measurement of polymer formation rate, elution pattern from Sephadex G-75,and sedimentation constant. 2) Citric acid and gluconic acid were also found by gel filtration to inhibit the hydrolytic polymerization of iron. These results suggest that the carbohydrates, polyols, and organic acids enhance the absorption of iron across the intestine by formation of low molecular polymers of iron.
公益社団法人日本薬学会の論文
1972-10-25