Metabolic Fate of ^<57>Co-Labeled Hydroxocobalamin and ^<57>Co-Labeled 5,6-Dimethylbenzimidazolylcobamide Coenzyme in Rats

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The metabolic fate of ^<57>Co-hydroxocobalamin (^<57>Co-OH-B_<12>) and ^<57>Co-5,6-dimethyl-benzimidazolylcobamide coenzyme (^<57>Co-DBCC) has been studied after intraperitoneal administration at the dosage of 25 μg/kg in rats. About 60% of radioactivity administered was recovered in urine during the first 24 hr after administration of ^<57>Co-OH-B_<12> or ^<57>Co-DBCC. The highest tissue uptake was found in kidney, especially after injection of ^<57>Co-DBCC, followed by adrenal gland, pancreas, stomach and liver. The distribution in brain, muscle and adipose tissue was much lower. It is evident that ^<57>Co-OH-B_<12> was converted to ^<57>Co-DBCC and reverse conversion of ^<57>Co-DBCC occured in liver and kidney. Furthermore, ^<57>Co-methylcobalamin (^<57>Co-CH_3-B_<12>) was found to be yielded from both the cobamides. The biological interconversion among ^<57>Co-CH_3-B_<12>, ^<57>Co-OH-B_<12>and ^<57>Co-DBCC was established.
公益社団法人日本薬学会の論文
1973-06-25