Studies on Lymphatic Absorption of 1', 2'-(^3H)-Coenzyme Q_<10> in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The intestinal absorption of 1', 2', -(^3H)-coenzyme Q_10 (^3H-Q-10) was studied in rats with cannulated thoracic duct and the effect of surface-active agents on the lymphatic absorption of ^3H-Q-10 was determined. The amount of radioactivity absorbed via lymphatics during the first 48 hr was 1 % of the dose after oral administration of ^3H-Q-10 dissolved in sesame oil or 20 mM sodium taurocholate, and was 1.5% of the dose of ^3H-Q-10 dissolved by HCO-60. Assuming that the amount of radioactivity recovered from urine (0.481%) and liver (0.004%) might come from the radioactivity absorbed via portal vein, the total amount of the radioactivity absorbed via portal vein and lymphatics was approximately 2% of the dose of ^3H-Q-10 dissolved by HCO-60 and the main route in absorption of ^3H-Q-10 was lymphatics. The model for lymphatic absorption of ^3H-Q-10 was proposed by kinetic analysis of the data.
- 公益社団法人日本薬学会の論文
- 1972-12-25
著者
-
藤田 孟
Department Of Drug Metabolism
-
藤田 孟
Department Of Drug Metabolism Section Of Experimental Therapeutics Research Research & Developme
-
片山 幸一
Tsukuba Research Laboratories, Eisai Co., Ltd.,
-
片山 幸一
Department of Drug Metabolism, Section of Experimental Therapeutics Research, Research & Development
-
片山 幸一
Tsukuba Research Laboratories Eisai Co. Ltd.
-
片山 幸一
Department of Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Company Ltd.
関連論文
- Structure-Activity Studies on Triazolothienodiazepine Derivaties as Platelet-Activating Factor Antagonists
- 各種分子量を有するXylitol-Iron-Citrate Complex の調製ならびにそれらComplex筋肉内注射時の鉄血中濃度および尿中排泄に対する分子量の影響
- Studies on Reduced and Oxidized Ubiquinones. I. Simultaneous Determination of Reduced and Oxidized Ubiquinones in Tissues and Mitochondria by High Performance Liquid Chromatography
- The Metabolic Fate of ^Co-Methylcobalamin in the Rat with a Crushed Sciatic Nerve-Especially on the Uptake by the Nerve Tissue and by Muscles innervated by Sciatic Nerves
- Metabolic Fate of ^Co-Labeled Hydroxocobalamin and ^Co-Labeled 5,6-Dimethylbenzimidazolylcobamide Coenzyme in Rats
- Metabolism of ^Co-Methylcobalamin in Rat and Guinea Pig
- Studies on Biotransformation of Lysozyme. II. Tissue Distribution of ^I-Labeled Lysozyme and Degradation in Kidney after Intravenous Injection in Rats
- Studies on Biotransformation of Lysozyme. I. Preparation of Labeled Lysozyme and Its Intestinal Absorption
- Absorption Route of ^I-Labeled Lysozyme in Rats
- Studies on Lymphatic Absorption of 1', 2'-(^3H)-Coenzyme Q_ in Rats
- Metabolism of Thiamphenicol and Comparative Studies of Its Urinary and Biliary Excretion with Chloramphenicol in Various Species
- Studies on Biotransformation of Lysozyme. IV. Radioimmunoassay of Lysozyme and Its Evaluation
- マスフラグメントグラフィーによる血漿中α-Tocopherolおよびα-Tocopheryl Acetateの同時定量
- 鉄の腸管吸収に関する研究(第1報)鉄塩の加水分解重合に対する糖, 多価アルコールおよび有機酸の影響
- Autoradiographic Study on the Distribution of ^I-Labeled Lysozyme after Intravenous Injection in Rats
- A Simple Purification Procedure for Rat Pancreatic Elastase and Radioimmunoassay of the Enzyme
- Targeting of coenzyme Q10 solubilized with soy lecithin to heart of guinea pigs.
- Changes in .GAMMA.-carboxyglutamic acid levels in acid-soluble and insoluble fractions of developing chick bones.