摘出平滑筋臓器におけるButoxybenzyl hyoscyamine bromideの薬理学的効果

概要

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Pharmacological properties of butoxybenzyl hyoscyamine bromide (BHB) on isolated smooth muscle organs; stomach, intestine, gall-bladder, urinary bladder and uterus of animals (mice, rats, guinea pigs and rabbits) were investigated and compared to atropine sulfate (Atr), hyoscin N-butyl bromide (HBB) and prifinium bromide (PB). The tonus and spontaneous motility of isolated smooth muscles were decreased by BHB at the concentration of 1×10-4_??_10-5g/ml and the effects of BHB were more potent than those of Atr, PB and HBB. Anticholinergic and antinicotinic actions of BHB were observed at a concentration over 1×10-9g/ml and these effects of BHB were almost equivalent to those of Atr and PB, and more potent than that of HBB. BHB showed relatively potent anti-BaCl2 action in the ileum and stomach, and Atr, PB and HBB were less potent than BHB in this regard. Antihistaminic and antiserotonic actions were also observed in a relatively high concentration of BHB.
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