家兎におけるChlorpropamideの腎排泄に及ぼす遊離脂肪酸の影響

概要

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The effect of free fatty acids in plasma of rabbits on plasma elimination and renal clearance of chlorpropamide (CPA) was studied. Drip infusion of 0.7 w/v% fat emulsion which elevated the free fatty acids concentration in plasma was made. When 50 mg/kg CPA was intravenously injected, the plasma elimination rate constant of CPA decreased. For the purpose of elucidating the cause, fat emulsion was intravenously injected and renal tubular secretion inhibitory test was conducted in accordance with the standard renal clearance method. The ratios of renal tubular secretion volume (S), renal tubular reabsorption volume (A), and urinary excretion volume (UV) of CPA to CPA glomerular filtration volume (GFR・P_f) were obtained, respectively. It was found that the ratio of renal tubular secretion volume to glomerular filtration volume (S/GFR・P_f) significantly decreased. These findings suggest that renal tubular secretion of CPA is inhibited by increasing free fatty acids concentration in plasma.
社団法人日本薬学会の論文
1983-12-25