内服糖尿病薬の治療効果と副作用

概要

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The purpose of this study is to investigate the controlled blood sugar level and incidence of adverse reactions in the controlled diabetic out-patients who had been treated with oral hypoglycemic agents. Change in blood sugar level and body weight of each of the 427 patients were recorded before and after the start of the therapy, and the variety and incidence of adverse reactions were analyzed. Of the 427 cases, 90% showed good or fair control indicating satisfactory blood sugar level. Weight reduction appeared to be mild in the group of patients receiving sulfonylurea, as compared with the group on biguanide. It was felt that more effective dietary care should be taken for this group. Low blood sugar level was noted in 10.4% of the sulfonylurea group. The results of this study indicate that in order to maintain an appropriate blood sugar control by sulfonylurea, occurrence of some mild cases of low blood sugar level are unavoidable.
日本医療薬学会の論文