各種血管収縮薬のリドカイン吸収と麻酔持続時間に対する影響

概要

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The effect of various adrenergic agents, adrenaline (Ad), noradrenaline (Nad), phenylephrine (Phe), methoxamine (Methox), isoproterenol (Isop) on ^<14>C-lidocaine (Lid) absorption, duration of anesthesia, heart rate and ECG were studied in guinea-pigs. The absorption of Lid administered intradermaly at the shaven back was increased with time and its peak was obtained after 70 min. Ad (0.1-1.0μg) administered with Lid inhibited about 50-61% of Lid absorption and the duration of Lid-anesthesia was prolonged to 11-56 min. Nad, Phe and Methox (moles equivalent to Ad 1.0μg) inhibited 37-45% of the absorption and prolonged the duration of anesthesia for 15-21 min. Three-fold dosages of Nad, Phe, Methox however prolonged the duration of anesthesia for about 43-58 min. Ad-produced inhibition of Lid-absorption was also observed even at intramuscular administration to the femoral region. The heart rate was increased by Ad 1.0μg at about 50 min, but immediately by Isop, together with a slight increase of P- and T-wave, shortening of the P-P interval on ECG. The other compound did not show any effect on the heart rate and ECG.
日本医療薬学会の論文
1987-06-20