カラゲニン浮腫ラットにおける肝薬物代謝酵素活性の低下(第2報)血漿中アンチピリン濃度への影響について

概要

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The variation of hepatic drug-metabolism was investigated in male Wistar rats bearing hind paw edema induced by carrageenan (1%, 0.1 ml, s. c.). The content of cytochrome P-450 and the biotransformation of aminopyrine in the hepatic 9000×g supernatant (S-9) decreased after the subcutaneous injection of carrageenan to rat hind paw. In carrageenan-treated rats the plasma concentration of antipyrine after the administration of antipyrine (20 mg/kg, i. v.) was higher than that of control rats. In comparison with the control groups, the pharmacokinetic parameters of antipyrine in carrageenan-treated rats was altered. AUC_<0-200> and t_<1/2> significantly increased and CL_<tot> and k_e significantly decreased. On the other hand, no change of the volume of distribution (V_d) was observed. The results indicate that the hepatic drug metabolism under the carrageenan-induced inflammation is inhibited both in vitro and in vivo.
公益社団法人日本薬学会の論文
1992-02-25