カエル卵レクチンの抗腫瘍性-1-ニホンアカガエル卵レクチンおよびウシガエル卵レクチンのマウスEhrlich固型癌に対する増殖抑制

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Effects of egg lectins from Rana japonica (RJ-lectin) and from Rana catesbiana (RC-lectin) on the growth of Ehrlich solid tumor were investigated in male ddY mice. The antitumor activity was estimated by weighing the solid tumor on the 10th day after the cell inoculation (1 × 10<SUP>6</SUP> cells). Intraperitoneal or subcutaneous administration of RJ-lectin (10 ?? 40 mg/kg) suppressed the tumor growth, and the inhibitory action of RJlectin was dose dependent. RJ-lectin at 10, 20, or 40 mg/kg (three intraperitoneal administrations) suppressed the tumor growth, the inhibition rate being 35, 56, or 69%, respectively, RC-lectin at a dose of 2.5, or 5.0 mg/kg (single intraperitoneal administration) also suppressed the growth, to a certain extent. The phagocytic activity in the mice was not changed by successive administration of RJ-lectin. Leakage of dye into the peritoneal cavity of mice increased with intraperitoneal injection of RJ-lectin after the intravenous injection of pontamine sky blue. This leakage also increased with RJ-lectin (1 mg) even in the immunosuppressive mouse treated with hydrocortisone. RJ-lectin is the first animal origin lectin to reveal an antitumor activity. RJ-lectin may therefore have a direct cytotoxic effect on tumor cells.
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